The NQO1 C609T polymorphism is associated with risk of secondary malignant neoplasms after treatment for childhood acute lymphoblastic leukemia: a matched-pair analysis from the ALL-BFM study group.

نویسندگان

  • Martin Stanulla
  • Christian Dynybil
  • Dorothee B Bartels
  • Michael Dördelmann
  • Lutz Löning
  • Alexander Claviez
  • Martin Schrappe
چکیده

In a matched-pair study, we analyzed the association of a phenotypically relevant NQO1 polymorphism (C609T) with risk of secondary malignant neoplasms (SMN) after treatment for childhood acute lymphoblastic leukemia. Patients carrying a variant low-activity NQO1 allele had a significantly increased risk of developing a SMN. The observed effect was restricted to solid tumors.

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Association of TPMT (rs1800460) Gene Polymorphism with Childhood Acute Lymphoblastic Leukemia in a Population from Guilan, Iran

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Secondary Malignant Neoplasm(SMN) is one of the late effects of childhood cancer. Among secondary malignancies, acute myeloid leukemia(AML) is the most common and life-threatening neoplasm. Secondary acute lymphoblastic leukemia(ALL) is rare and only 10% of SMN is ALL. Patients with Wilm’s tumor are not protected from the secondary cancers after the primary diagnosis. Among patients...

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عنوان ژورنال:
  • Haematologica

دوره 92 11  شماره 

صفحات  -

تاریخ انتشار 2007